Scoping and Problem Formulation for the Toxicological Review of Polychlorinated Biphenyls (PCBs): Effects Other Than Cancer Draft
Author:
US Environmental Protection Agency (USEPA)
Date Published:
4/2015
Description:
In this document the IRIS program is releasing information on the scope of its upcoming assessment of polychlorinated biphenyls and is inviting the public to participate in the problem formulation by identifying the key issues and scientific information available for the assessment. The National Research Council’s Review of EPA’s IRIS Process (NRC, 2014) discussed scoping and problem formulation as these activities apply specifically to IRIS assessments. IRIS assessments critically review the scientific literature to identify potential human health hazards of chemicals in the environment and to characterize exposure-response relationships. Accordingly, the NRC discussed scoping and problem formulation for IRIS assessments as covering the scientific questions that pertain only to hazard identification and dose-response assessment. Exposure assessment and risk characterization (the other components of a risk assessment) are outside the scope of IRIS assessments, as are the legal, political, social, economic, and technical aspects of risk management. This document begins with brief background information on PCBs, continues with the scope of the upcoming assessment and the three problem-formulation steps that the NRC suggested, and concludes with a preliminary discussion of key issues. Portions of this document were adapted from the Toxicological Profile for Polychlorinated Biphenyls (PCBs) (ATSDR, 2011, 2000) under a Memorandum of Understanding with the Agency for Toxic Substances and Disease Registry (ATSDR) entered into as part of a collaborative effort in the development of human health toxicological assessments for the purposes of making more efficient use of available resources and to share scientific information. Scoping and Problem Formulation for the Toxicological Review of Polychlorinated Biphenyls (PCBs): Effects Other Than Cancer Draft: originally available at http://www.epa.gov/ncea/iris/publicmeeting/iris_bimonthly-jun2015/pcbs_pf_scoping_april2015.pdf, last accessed July 30, 2015.
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